Whole seeds of Bauhinia variegata L. (Fabaceae) as an efficient biocatalyst for benzyl alcohol preparations from benzaldehydes

Demmel, Gabriela Inés ORCID: https://orcid.org/0000-0002-6939-1391, Bordón, Daniela L. ORCID: https://orcid.org/0000-0001-5211-6564, Vázquez, Ana María ORCID: https://orcid.org/0000-0002-8466-3471, Decarlini, María Florencia ORCID: https://orcid.org/0000-0002-9093-6990, Díaz Panero, Mariángeles, Rossi, Laura I. and Aimar, Mario Leandro ORCID: https://orcid.org/0000-0001-8547-7198 (2021) Whole seeds of Bauhinia variegata L. (Fabaceae) as an efficient biocatalyst for benzyl alcohol preparations from benzaldehydes. Biocatalysis and Biotransformation. ISSN 1024-2422

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Resumen

Whole seeds of Bauhinia variegata L. (Fabaceae) were utilized as a biological reducer to transform benzaldehyde into benzyl alcohol. The effects of some variables such as temperature, the load of substrate and co-solvent, were established to optimize the reductive process. Utilizing the optimal reaction conditions, a laboratory-scale reaction (final concentration of the substrate: 21.2 mM) was performed to obtain benzyl alcohol (conversion: 95%; isolated yield: 49%; productivity: 1.11 g L−1 or 0.046 g L−1h−1 of benzyl alcohol). In addition, using these optimal conditions, fourteen substituted benzaldehydes were reduced, with a conversion achieved to their corresponding benzyl alcohols ranging from 62% to >99% (isolated yields from 7% to 70%). Moreover, useful building blocks by the synthesis of the drugs and important commercial products were also obtained. The scope, limitations and advantages of this new biocatalytic synthetic method are also discussed.

Tipo de documento:	Artículo
DOI:	https://doi.org/10.1080/10242422.2021.1956910
Palabras clave:	Bauhinia variegata. Benzaldehídos. Semillas. Biocatálisis.
Temas:	Q Ciencia > QD Química
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias Químicas
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/3320

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