Extended-spectrum β-lactamases in Klebsiella pneumoniae isolated in a pediatric Hospital of Córdoba, Argentina [β-Lactamasas de espectro extendido en Klebsiella pneumoniae aisladas en el Hospital de Niños de Córdoba, Argentina]

Saka, H.A., Egea, M., Culasso, C., Rollan, R., Avaro, A. and Carvajal, L. (2003) Extended-spectrum β-lactamases in Klebsiella pneumoniae isolated in a pediatric Hospital of Córdoba, Argentina [β-Lactamasas de espectro extendido en Klebsiella pneumoniae aisladas en el Hospital de Niños de Córdoba, Argentina]. Revista Argentina de Microbiología, 35 (1). pp. 1-7. ISSN 0325-7541

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Resumen

The aim of the present study was to investigate the presence of extended-spectrum β-lactamases (ESBL) in Klebsiella pneumoniae isolated at the "Hospital de Niños de Córdoba". The strains were collected from inpatients between January 1996 and July 2000. A total of 150 ESBL producer isolates were detected. During 1996 the prevalence of ESBL producer K. pneumoniae was 20%, but since 1998 the values have increased to approximately 60%. Phenotypic analysis such as isoelectric point (pl) and antibiotyping performed in 32 randomly selected isolates showed two different enzyme profiles: 81% had ESBL with pl=7.9 and preferential activity against cefotaxime, while 19% showed ESBL with pl=5.4 and preferential activity against ceftazidime. No isolates resistant to imipenem or ciprofloxacin were detected. Susceptibility to other antimicrobial agents varied, but resistance to gentamicin was strongly associated with ESBL producer isolates. Resistance determinants could be transferred to Escherichia coliby conjugation assays.

Tipo de documento:	Artículo
Palabras clave:	Antimicrobial resistance. Extended-spectrum β-lactamases. Klebsiella pneumoniae. Pediatric infections. Third generation cephalosporins.
Temas:	Q Ciencia > QD Química
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias Químicas
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/3969

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