Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies

Re, Viviana Elizabeth ORCID: https://orcid.org/0000-0002-4106-6642, Gallego, Sandra Verónica, Treviño, Elena, Barbás, María Gabriela, Dominguez, Claudia, Elbarcha, Osvaldo César, Bepre, Héctor and Contigiani, Marta Silvia ORCID: https://orcid.org/0000-0002-7171-0013 (2005) Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies. Memorias do Instituto Oswaldo Cruz, 100 (3). pp. 303-307. ISSN 0074-0276

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Resumen

This study was conducted to compare among the most recent generation of five screening tests licensed in Argentina, in order to evaluate which of the tests has the best sensitivity for detection of antibodies against hepatitis C virus (HCV). The tests analyzed were: Detect-HCV™ (3.0) Biochem ImmunoSystems, Canada; Hepatitis C EIA Wiener Lab., Argentina; Equipar HCV Ab, Italy; Murex HCV 4.0, UK and Serodia-HCV particles agglutination test, Japan. The results obtained showed high discrepancy between the different kits used and show that some of the tests assessed have a low sensitivity for anti-HCV detection in both chronic infections and early seroconversion, and indicate that among the commercially available kits in Argentina, Murex HCV 4.0 (UK) and Serodia-HCV particles agglutination test (Japan) have the best sensitivity for HCV screening. Although the sensitivity of the assays is the first parameter to be considered for blood screening, more studies should be carried out to assess the specificity of such assays.

Tipo de documento:	Artículo
DOI:	https://doi.org/10.1590/S0074-02762005000300016
Palabras clave:	HCV screening test. Hepatitis C virus (HCV). Sensitivity.
Temas:	R Medicina > R Medicina (General)
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias de la Salud
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/3990

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