Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States

Steinmaus, Craig ORCID: https://orcid.org/0000-0003-2697-843X, Bates, Michael N., Yuan, Yan, Kalman, Dave, Atallah, Raja, Rey, Omar A. ORCID: https://orcid.org/0000-0002-9232-1252, Biggs, Mary Lou, Hopenhayn, Claudia, Moore, Lee E., Hoang, Bruce K. and Smith, Allan H. (2006) Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States. Journal of Occupational and Environmental Medicine, 48 (5). pp. 478-488. ISSN 1076-2752

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Resumen

Objective: We sought to assess whether the metabolism of arsenic impacts a person's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argentina, the adjusted odds ratio (OR) for subjects with a high proportion of ingested arsenic excreted as monomethylarsonate (%MMA) was 2.17 (95% confidence interval [CI] = 1.02-4.63) in smokers and 0.48 (95% CI = 0.17-1.33) in nonsmokers. In the United States, the adjusted ORs for high %MMA in subjects with arsenic intakes less than and greater than 100 μg/d were 1.20 (95% CI = 0.27-5.38) and 2.70 (95% CI = 0.39-18.6). Conclusions: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer.

Tipo de documento:	Artículo
DOI:	https://doi.org/10.1097/01.jom.0000200982.28276.70
Palabras clave:	Aged. Arsenic. Case-Control Studies. Methylation. Middle Aged. Odds Ratio. United States. Urinary Bladder Neoplasms.
Temas:	R Medicina > R Medicina (General)
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias de la Salud
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/4002

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