Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle

Baroni, Eduardo E., Díaz, Diego C., Picco, Eduardo, Waxman, Samanta, Rodriguez Fenández, Casilda, San Andrés-Larrea, Manuel Ignacio ORCID: https://orcid.org/0000-0003-1829-6113 and Boggio, Juan Carlos ORCID: https://orcid.org/0000-0001-9748-001X (2008) Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle. Veterinary Research Communications, 32 (7). pp. 509-519. ISSN 0165-7380

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Resumen

Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/ PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in ≥7 weeks-old cattle to reach a satisfactory dosage regimen (MIC≥32 μg/mL).

Tipo de documento:	Artículo
DOI:	https://doi.org/10.1007/s11259-008-9053-y
Palabras clave:	Age. Cattle. Pharmacokinetics. PK/PD. Sulfamethazine.
Temas:	S Agricultura > SF Cultura de los animales
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias Agropecuarias
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/4190

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