Administration of a Peptide Inhibitor of α4-Integrin Inhibits the Development of Experimental Autoimmune Uveitis

Martín, Andrea P., Vieira de Moraes, Luciana, Tadokoro, Carlos E., Commodaro, Alessandra G., Urrets Zavalía, Enrique Alberto, Rabinovich, Gabriel A., Urrets Zavalía, Julio ORCID: https://orcid.org/0000-0003-2267-2783, Rizzo, Lucio V. and Serra, Horacio M. ORCID: https://orcid.org/0000-0003-4979-8642 (2005) Administration of a Peptide Inhibitor of α4-Integrin Inhibits the Development of Experimental Autoimmune Uveitis. Investigative Ophthalmology & Visual Science, 46 (6). pp. 2056-2063. ISSN 0146-0404

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Resumen

Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. alpha4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of alpha4-integrin inhibitor on the development of EAU was investigated.

Tipo de documento:	Artículo
Palabras clave:	Uveitis. Suppression. Peptide. Anti Integrin.
Temas:	R Medicina > RE Oftalmología
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias de la Salud
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/4272

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