Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve

Cafaro, Thamara A., Santo, Stefanía, Robles, Lucena A., Crim, Nicolás, Urrets Zavalía, Julio ORCID: https://orcid.org/0000-0003-2267-2783 and Serra, Horacio M. ORCID: https://orcid.org/0000-0003-4979-8642 (2010) Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve. Molecular Vision, 16. pp. 1654-1658. ISSN 20806090

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Resumen

Purpose: To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. Methods: Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. Results: We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). Conclusions: This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.

Tipo de documento:	Artículo
Palabras clave:	Aged. Aged, 80 and over. Citrulline. Enzyme-Linked Immunosorbent Assay. Female. Glaucoma. Humans. Hydrolases.Immunohistochemistry. Male. Middle Aged. Optic Nerve. Tissue Donors.
Temas:	R Medicina > R Medicina (General)
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias Químicas Universidad Católica de Córdoba > Facultad de Ciencias de la Salud
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/4971

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