Producción Académica UCC

Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat

Crescente, Juan M., Zavallo, Diego ORCID:, del Vas, Mariana ORCID:, Asurmendi, Sebastián ORCID:, Helguera, Marcelo ORCID:, Fernández, Elmer Andrés ORCID: and Vanzetti, Leonardo S. ORCID: (2022) Genome-wide identification of MITE-derived microRNAs and their targets in bread wheat. BMC Genomics, 23 (1). ISSN 1471-2164

[img] PDF
Disponible bajo Licencia CC Atribución-NoComercial-SinDerivadas 4.0 Internacional.

Descargar (71kB)
URL Oficial:


Background: Plant miRNAs are a class of small non-coding RNAs that can repress gene expression at the post-transcriptional level by targeting RNA degradation or promoting translational repression. There is increasing evidence that some miRNAs can derive from a group of non-autonomous class II transposable elements called Miniature Inverted-repeat Transposable Elements (MITEs). Results: We used public small RNA and degradome libraries from Triticum aestivum to screen for microRNAs production and predict their cleavage target sites. In parallel, we also created a comprehensive wheat MITE database by identifying novel elements and compiling known ones. When comparing both data sets, we found high homology between MITEs and 14% of all the miRNAs production sites detected. Furthermore, we show that MITE-derived miRNAs have preference for targeting degradation sites with MITE insertions in the 3’ UTR regions of the transcripts. Conclusions: Our results revealed that MITE-derived miRNAs can underlay the origin of some miRNAs and potentially shape a regulatory gene network. Since MITEs are found in millions of insertions in the wheat genome and are closely linked to genic regions, this kind of regulatory network could have a significant impact on the post-transcriptional control of gene expression.

Tipo de documento: Artículo
Palabras clave: miARN. ARN. Expresión génica.
Temas: Q Ciencia > Q Ciencia (General)
Q Ciencia > QK Botánica
Unidad académica: Universidad Católica de Córdoba > Unidad Asociada a CONICET
Google Académico: Citaciones en Google Académico Ver citaciones
Ver item Editar ítem

Descargas mensuales a lo largo de los últimos 12 meses

Producción Académica UCC soporta OAI 2.0 con una URL base

Sistema de Bibliotecas
Universidad Católica de Córdoba
Campus Universitario. Avenida Armada Argentina 3555
Córdoba, Argentina

Sistema Nacional de Repositorios Digitales (SNRD) EPrints Logo