Diurnal ACTH and plasma cortisol variations in healthy dogs and in those with pituitary-dependent Cushing's syndrome before and after treatment with retinoic acid

Castillo, V.A., Cabrera Blatter, M.F., Gómez, N.V., Sinatra, V., Gallelli, M.F. and Ghersevich, María Carolina ORCID: https://orcid.org/0009-0008-7577-4402 (2009) Diurnal ACTH and plasma cortisol variations in healthy dogs and in those with pituitary-dependent Cushing's syndrome before and after treatment with retinoic acid. Research in Veterinary Science, 86 (2). pp. 223-229. ISSN 18692856

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Resumen

Daytime variations in ACTH and plasma cortisol were studied in healthy dogs and in dogs with pituitary-dependent hypercortisolism (PDH), before and after treatment with retinoic acid. In control dogs ACTH showed a higher concentration at 8.00 AM and between 2.00 and 6.00 PM, with the lowest concentration registered at 10.00 AM (p < 0.05 vs. 8.00 AM and 2.00 PM and p < 0.01 vs. 4.00 PM). Cortisol did not show significant differences. In dogs with PDH, ACTH was lower at 8.00 AM (ACTH: p < 0.01 vs. 2.00 and 4.00 PM; and p < 0.05 vs. 6.00 PM). The lowest cortisol concentration was registered at 8.00 AM and 8.00 PM and the highest at 4.00 PM (p < 0.05 vs. 8.00 AM and p < 0.01 vs. 8.00 PM). After treatment, the lowest ACTH concentration was registered at 10.00 AM (p < 0.01 vs. 2.00 and 4.00 PM). To conclude, the adrenal is desensitized in PDH possibly showing negative in diagnostic tests.

Tipo de documento:	Artículo
DOI:	https://doi.org/10.1016/j.rvsc.2008.06.006
Información adicional:	ACTH diurnal rhythm. Cortisol diurnal rhythm. Cushing's disease. Pituitary-dependent hypercortisolism. Retinoic acid.
Temas:	S Agricultura > SF Cultura de los animales
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias Agropecuarias
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/4944

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