Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia

Elías, Eliana Vanina ORCID: https://orcid.org/0000-0003-2516-9219, Gottig, Natalia ORCID: https://orcid.org/0000-0002-8730-8248, Quiroga, Rodrigo ORCID: https://orcid.org/0000-0001-5015-0531 and Luján, Hugo Daniel ORCID: https://orcid.org/0000-0002-3797-8315 (2009) Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia. Giardia and Cryptosporidium: From Molecules to Diseases. ISSN 9781845933913

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Resumen

Giardia lamblia trophozoites lack organelles typical of higher eukaryotes such asmitochondria, peroxisomes and compartments involved in intracellular protein traffickingand secretion, the Golgi apparatus and secretory granules. Nevertheless, the minimalmachinery for protein transport and sorting is present in this parasite. When Giardiaundergoes encystation, the biogenesis of secretory organelles necessary to transport cystwall constituents to the cell surface takes place. Although both constitutive and regulatedpathways for protein secretion exist in Giardia, little is known about the molecules andmechanisms specifically involved in vesicular docking and fusion. In higher eukaryotes,soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) of thevesicle-associated membrane protein (VAMP) and syntaxin proteins play an essential rolein these processes through the formation of complexes between proteins present on donorand target membranes. Recent studies in both vegetative and encysting trophozoiteshave provided interesting information regarding the secretory pathway of this importantpathogen.

Tipo de documento:	Artículo
Temas:	R Medicina > R Medicina (General)
Unidad académica:	Universidad Católica de Córdoba > Facultad de Ciencias de la Salud
Google Académico:	Ver citaciones
URI:	http://pa.bibdigital.ucc.edu.ar/id/eprint/4948

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